In 1889, Caroline Hampton was a talented young nurse working at Johns Hopkins Hospital in Baltimore. She was the chief nurse in the medical team working with William Halsted, one of the founders of the hospital and a well-known surgeon. After a few months of assisting in the operating room, Caroline was on the verge of resigning from her position due to painful eczema and dermatitis she had developed as a result of following Halsted’s strict hygienic procedure that included disinfecting hands and instruments with multiple chemical solutions. The surgeon didn’t want to part with his favorite assistant, so he came up with a brilliant idea:
“In the winter of 1889 and 1890, I cannot recall the month, the nurse in charge of my operating-room complained that the solutions of mercuric chloride produced a dermatitis of her arms and hands. As she was an unusually efficient woman, I gave the matter my consideration and one day in New York requested the Goodyear Rubber Company to make as an experiment two pair of thin rubber gloves with gauntlets. On trial, these proved to be so satisfactory that additional gloves were ordered. (…) After a time the assistants became so accustomed to working in gloves that they also wore them as operators and would remark that they seemed to be less expert with the bare hands than with the gloved hands.” 
The use of rubber gloves saved not only the nurse’s hands, but also patients’ health – the hospital reduced the post-op infection rates from 17% to 2%. A few years after Halsted introduced his invention, the gloves were improved and sterilized by our champion of the germ theory of disease – Joseph Lister. 
The only thing the gloves didn’t save was the nurse’s position at the hospital. Caroline and William fell in love and got married in June of 1890. 
At that point, she had to resign from her job, as it was seen unfit for a married woman to continue to work. It is said that their marriage was quite successful, and they were seen as a pair of eccentrics, enjoying the company of their pets and unusual hobbies.
Halsted’s unusal life has been described in many books that could interest you, e.g., “Genius on the Edge” by Gerald Imber.
In the pre-germ-theory world, dirty clothes, unwashed linens, festering wounds, and limited access to clean water were pretty standard for a hospital experience, followed by outbursts of such diseases like rubella or cholera. 
Unfortunately, many surgeons contributed to this situation by not washing their hands, not disinfecting surgical instruments, and … glorifying their blood-soaked frock coats and surgical aprons. 
Some surgeons even wore clothes that had previously belonged to retired staff members as a sign of respect and keeping traditions alive. Those who wore “butcher’s aprons” mostly did so to protect their private, nice clothing and didn’t wash them anyway. As you can imagine, these pus- and blood-soaked, never-washed items were basically rotting and gave out a putrid smell which was lovingly referred to as “the good old hospital stink.” 
The sanitary regime was non-existent and the putrid smells of disease, dirty linens, and unwashed clothes penetrated the hospital building and its walls. While wealthier people were cared for in their own homes, the poor were forced to withstand awful hospital conditions, where the probability of dying was three to five times higher than in a household. (That’s why hospitals used to be called “houses of death”). 
veinityfair.com 